Adjunct Senior Principal Investigator
luotp@szbl.ac.cn
Home page of research group：https://www.chem.pku.edu.cn/luotp/
2019 - Present Peking University Associate Professor
2013 - 2019 Peking University Assistant Professor
2011 - 2013 H3 Biomedicine Inc. Postdoctoral Fellow
2005 - 2011 Harvard University PhD
2001 - 2005 Peking University Bachelor
Research Areas
Our group focuses on areas of organic chemistry and chemical biology in order to provide useful small molecules and tools to facilitate researches in life sciences. Specifically, we aim at 1) exploring and applying novel chemical reactions with the goal to advance synthetic organic chemistry and chemical biology, 2) collaborating with biology research groups to shed light on intriguing problems in life sciences, and 3) discovering innovative approaches to address the demanding medical needs of human beings.
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Highlights
Tuoping Luo was born on 1982 in Fujian, China. He won a Gold Medal in the 33rd International Chemistry Olympiad (IChO, 2001) during high school. From 2001 to 2005, he studied chemistry at Peking University and performed undergraduate research in Professor Zhen Yang’s group. In 2011, He received his Ph.D. degree with Professor Stuart L. Schreiber at Harvard University and Broad Institute. He did his post-doctorate research under the supervision of Dr. John Wang in H3 Biomedicine Inc., a start-up company focusing on oncology drug development. He returned to Peking University in 2013 and started his independent group, which concentrates on the development of biologically active small molecules. He was promoted to associate professor with tenure on 2019. His group aims to investigate the efficient synthesis and chemical biology problems of small molecules with important biological activities, especially structurally complex natural products. Highlighted synthetic achievements in the past few years include vinigrol, pseudopterosin A, caribenol A, ent-kauranoids, vinblastine, wortmannin, and batrachotoxinin A. These works not only have provided efficient and scalable preparation methods for a number of complex natural products with important biological activities, but also lay the foundation for tackling the synthetic challenges of even more complex molecules and the application of structurally and biologically unique compounds provided by our synthetic program. He was awarded Thieme Chemistry Journal Award (2017) and the 7th CSC-RSC Distinguished Young Investigator Award.
Honors
• 2013 The Recruitment Program of Global Youth Experts
• 2017 Thieme Chemistry Journal Award
• 2017 Greenleaf Distinguished Young Investigator in Biomedical Research
• 2019 The 7th CSC-RSC Distinguished Young Investigator Award
Selected Publications
1. Chen, H.; Li, Z.; Shao, P.; Yuan, H.; Chen, S.-C.; Luo, T.* Total Synthesis of (+)-Mutilin: A Transannular [2+2] Cycloaddition/Fragmentation Approach. J. Am. Chem. Soc. 2022, 144, 15462−15467.
2. Kong, L.; Yu, H.; Deng, M.; Wu, F.; Jiang, Z.; Luo, T.* Enantioselective Total Syntheses of Grayanane Diterpenoids: (–)-Grayanotoxin III, (+)-Principinol E, and (–)-Rhodomollein XX. J. Am. Chem. Soc. 2022, 144, 5268−5273.
3. Fang, X.; Zhang, N.; Chen, S.-C.; Luo, T.* Scalable Total Synthesis of (–)-Triptonide: Serendipitous Discovery of a Visible-Light-Promoted Olefin Coupling Initiated by Metal-Catalyzed Hydrogen Atom Transfer (MHAT). J. Am. Chem. Soc. 2022, 144, 2218−2224.
4. Chen, S.-C.; Zhu, Q.; Cao, Y.; Li, C.; Guo, Y.; Kong, L.; Che, J.; Guo, Z.; Chen, H.; Zhang, N.; Fang, X.; Lu, J.-T.; Luo, T.* Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation. J. Am. Chem. Soc. 2021, 143, 14046−14052.
5. Cai, Y.#; Zhou, H.#; Zhu, Y.#; Sun, Q.; Ji, Y.; Xue, A.; Wang, Y.; Chen, W.; Yu, X.; Wang, L.; Chen, H.; Li, C.; Luo, T.*; Deng, H.* Elimination of Senescent Cells by β-Galactosidase-Targeted Prodrug Attenuates Inflammation and Restores Physical Function in Aged Mice. Cell Res. 2020, 30, 574−589.
6. Guo, Y.; Guo, Z.; Lu, J.-T.; Fang, R.; Chen, S.-C.; Luo, T.* Total Synthesis of (–)-Batrachotoxinin A: A Local-Desymmetrization Approach. J. Am. Chem. Soc. 2020, 142, 3675−3679.
7. Kong, L.#; Su, F. #; Yu, H.; Jiang, Z.; Lu, Y.; Luo, T.* Total Synthesis of (–)-Oridonin: An Interrupted-Nazarov Approach. J. Am. Chem. Soc. 2019, 141, 20048−20052.
8. Yu, X.; Xiao, L.; Wang, Z.; Luo, T.* Scalable Total Synthesis of (–)-Vinigrol. J. Am. Chem. Soc. 2019, 141, 3440−3443.
9. Guo, Y. #; Quan, T. #; Lu, Y.; Luo, T.* Enantioselective Total Synthesis of (+)-Wortmannin. J. Am. Chem. Soc. 2017, 139, 6815−6818.
10. Yu, X.; Su, F.; Liu, C.; Yuan, H.; Zhao, S.; Zhou, Z.; Quan, T.; Luo, T.* Enantioselective Total Syntheses of Various Amphilectane and Serrulatane Diterpenoids via Cope Rearrangements. J. Am. Chem. Soc. 2016, 138, 6261−6270.