Junior Principal Investigator
zhang_adam@szbl.ac.cn
2021- Present Shenzhen Bay Laboratory Junior Principal Investigator
2016 - 2021 The Children's Hospital of Philadelphia Postdoc Fellow
2011 - 2016 University of Maryland College Park Ph.D.
2007 - 2011 Tongji University B.S.
Research Areas
Epigenetics, genomics, 3D genomics, transcription regulation and disease, mitosis, aging.
Highlights
• Established an in-vitro induction and differentiation system for vascular smooth muscle cells from premature aging HGPS patients.
• Revealed the molecular mechanism of HGPS smooth muscle cell death, providing noval therapeutic potential for the treatment of HGPS patients.
• Revealed the process of chromatin 3D structural reconfiguration during the mitosis to G1 phase transition; uncovered the dynamic process of post-mitotic chromatin recruitment of the architectural protein CTCF and cohesin ring complex; provides noval supports for the regulation role of loop extrusion model in post-mitotic chromatin 3D structural reconfiguration.
• Uncovered the relationship between chromatin 3D structural reconfiguration and transcription reactivation after mitosis.
• Uncovered the role of architecture protein CTCF in the reconfiguration of chromatin 3D structure after mitosis.
Has been publishing in prestigious journals including Nature, PNAS, Aging Cell etc.
Reestablishment of chromatin A/B compartments during the mitosis to G1 phase transition
Honors
• 2017 Charles A. Caramello Distinguished Dissertation Award, University of Maryland College Park
• 2014 MOCB Travel Award, University of Maryland College Park
• 2014 BISI Merit Student Award, University of Maryland College Park
• 2013 Best Poster Presentation Award. University of Maryland, School of Medicine
• 2011 Dean' s Fellowship, University of Maryland College Park
• 2011 Best Thesis Award, Tongji University
• 2010 China National Scholarship, Ministry of Education, China
• 2009 First Class Scholarship, Tongji University
• 2009 Shanghai Scholarship, Shanghai Education Commission, China
Selected Publications
1. Zhang, H., Emerson, D. J., Gilgenast, T. G., Titus, K. R., Lan, Y., Huang, P., ... Blobel, G. A. (2019). Chromatin Structure Dynamics During the Mitosis-to-G1 Phase Transition. Nature, 576(7785), 158-162. | DOI:10.1038/s41586-019-1778-y
2. Zhang H and Cao K (2016). Mechanisms of Genome Instability in Hutchinson-Gilford Progeria. Frontiers in Biology, DOI 10.1007/s11515-016-1435-x
3. Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C and Cao K (2016). Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. Plos ONE, 11(12) e0167454. doi: 10.1371/journal. pone.0167454. PMID: 27907109
4. Zhang H, Xiong Z and Cao K (2014). Mechanisms Controlling the Smooth Muscle Cell Death in Progeria via Down-Regulation of poly(ADP-ribose) Polymerase 1. PNAS, 111(2) 2261-2270.
5. Zhang H, Keickhaefer JE and Cao K. (2013) Mouse Models of Laminopathies. Aging Cell, 12(1) 2-10.