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Yi RAO    饶毅





Institute of Molecular Physiology

convenor ，Senior Principal Investigator

yrao@pku.edu.cn



  • 2019-                          President, Capital Medical University

  • 2018-present             Director, Chinese Institute for Brain Research, Beijing

  • 2012-present             Director, PKU-IDG/McGovern Institute for Brain Research

  • 2007-present             Chair Professor, Peking University, Beijing, China




Professional Experience

  • 2011-2020                Director, Peking-Tsinghua Center for Life Sciences

  • 2016-2019                Dean, Division of Sciences, Peking University

  • 2007-2013                Dean, School of Life Sciences, Peking University, Beijing, China

  • 2006-2007                Elsa Swanson Professor of Neurology, Northwestern Univ Sch Med

  • 2006-2007                Director of Research, Feinberg Clinical Neuroscience Research Institute

  • 2004-2006                Professor of Neurology  Northwestern Univ Feinberg Sch Med

  • 2004-2006                Deputy Director, Institute of Neuroscience, Northwestern University Chicago, IL, USA

  • 1994-2004                Assistant, Associate, Professor of Neurobiology Department of Anatomy and Neurobiology Washington University School of                                                      MedicineSt. Louis, MO, USA




Adjunct Appointments

  • 2022-                        Adjunct Professor 

                                     Department of Chemical Biology 

                                   School of Chemistry and Molecular Engineering 
                                 Peking University

  • 2021-                        Adjunct Professor 

                                     School of Pharmacy 

                                     Peking University Health Sciences Center

  • 2021-                        Adjunct Professor 

                                 Department of Pharmacology 
                                 School of Pharmacy
                                 Peking University Health Sciences Center

  • 2004-2009                Investigator and Deputy Director for Academic Affairs,

                                     National Institute of Biological Sciences, Beijing

  • 2007-2012                Adjunct Professor of Neurology, Northwestern Univ Sch Med

  • 2008-2011                Adjunct Professor of Biochemistry, Hong Kong Univ Sci & Tech

  • 2002-2005                Co-Director

                                Shanghai Institute of Advanced Studies,  Chinese Academy of Sciences




Education

  • 1991-1994                Postdoctoral Fellow

                                     Department of Biochemistry and Molecular Biology

                                     Harvard University

                                     Advisor: Dr. Douglas A. Melton

  • 1985-1991                Ph. D. in Neuroscience

                                     University of California, San Francisco

                                     Advisors: Drs. Lily Y. and Yuh-Nung Jan

  • 1983-1985               Graduate Student

                                    Department of Neurobiology

                                    Shanghai Medical University

                                    Advisor: Dr. A. Z. Zhang

  • 1978-1983               Medical Student         

                                    Jiangxi Medical College




Professional Service

  • 2018-                      Member, Medical Advisory Committee, Canadian Gairdner International Award

  • 2000                       Chair,       Gordon Conference on Molecular and Cellular Neurobiology

  • 2020-                      Editorial Board,        Genetics

  • 2018-                      Editorial Board,       Molecular and Cellular Neuroscience

  • 2017-                      Editorial Board,       Neuroscience

  • 2016-2017              Editorial Board,       Developmental Neurobiology

  • 2008-                      Reviews Editor,        Frontier in Neural Circuits

  • 2006-2021              Editorial Board,       Developmental Biology

  • 2002-2005              Editorial Board,       Developmental Brain Research

  • 2001-2006              Editorial Board,       Journal of Neuroscience

  • 2001-2008              Editorial Board,       NeuroSignals

  • 2001-2006              Editorial Board,       Faculty of 1000

  • 2000-2006              Editorial Board,       Neuroscience Research




Publications

Reviews and Book Chapters:

1) Wu JY and Rao Y (1999). Fringe: defining borders by regulating the Notch pathway. Curr. Op. Neurobiol. 9:537-543.

2) Wu JY and Rao Y (2001). Neuronal migration and the evolution of the human brain. Nature Neuroscience 4:860-862.

3) Wong K, Wu JY and Rao Y (2002). Neuronal migration. Encyclopedia of Life Sciences, Nature Publishing Group

4) Park HT, Wu JY and Rao Y (2002). Molecular control of neuronal migration. BioEssays 24:821-827.

5) Wong K, Park HT, Wu JY and Rao Y (2002). Slit proteins: guidance cues for cells ranging from neurons to leukocytes. Curr Op Genet Dev 12:583-591.

6) Rao Y, Wong K, Ward M, Jurgensen C and Wu JY (2002). Neuronal migration and molecular conservation with leukocyte chemotaxis. Genes Dev 16:2973-2984.

7) Guan KL and Rao Y (2003). Signal transduction mechanisms mediating neuronal responses to guidance cues. Nature Rev Neurosci 4:941-956.

8) Ward ME and Rao Y (2004). Investigations of neuronal migration in the central nervous system. In Guan, J.-L. (ed) Cell Migration: Developmental Methods and Protocols. Humana Press, Totowa, NJ. Methods Mol Biol. 294:137-56.

9) Liu G and Rao Y (2004). Neuronal migration in the central nervous system. The Cognitive Neurosciences, 3rd edition, Gazzaniga MS, editor in chief, MIT press.

10) Jiang H and Rao Y (2005). Axon formation: fate versus growth. Nature Neurosci 8:544 – 546.

11) Rao Y (2019) The first hormone: adrenaline. Trends in Endocrinology and Metabolism 30:331-334.



Original Research Papers:

1) Rao Y, Jan LY and Jan YN (1990). Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature 345:163-167.

2) Rao Y, Vaessin H, Jan LY and Jan YN (1991). Neuroectoderm in Drosophila embryos is dependent on the mesoderm for the positioning but not for formation. Genes Dev 5:1577-1588.

3) Rao Y, Bodmer R, Jan LY and Jan YN (1992). The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system. Development 116:31-40.

4) Rao Y (1994). Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor. Genes & Dev. 8:939-947.

5) Wu JY, Wen L, Zhang, WJ and Rao Y (1996). The secreted product of Xenopus lunatic fringe, a vertebrate signaling molecule. Science 273:355-358.

6) Li HS, Tierney C, Wen L, Wu JY and Rao Y (1997). A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm. Development 124:603-615.

7) Li HS, Chen JH, Wu W, Fagaly T, Yuan WL, Zhou L, Dupuis S, Jiang Z, Nash W, Gick C, Ornitz D, Wu JY and Rao Y (1999). Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons. Cell 96:807-818.

8) Wu W, Wong K, Chen JH, Jiang ZH, Dupuis S, Wu JY and Rao Y (1999). Directional guidance of neuronal migration in the olfactory system by the secreted protein Slit. Nature 400:331-336.

9) Zhu Y, Li HS, Zhou L, Wu JY and Rao Y (1999). Cellular and molecular guidance of GABAergic neuronal migration from an extra-cortical origin to the neocortex. Neuron 23: 473-485.

10) Yuan W, Zhou L, Chen JH, Wu JY, Rao Y and Ornitz DM (1999). The mouse Slit family: secreted ligands for Robo expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev. Biol. 212:290-306.

11) He M, Wen L, Campbell C, Wu JY and Rao Y (1999). Transcription repression by ET, an ortholog of human Tbx3, a gene involved in ulnar-mammary syndrome. Proc. Natl. Acad. Sci. USA 96:10212-10217.

12) Chen J, Wu W, Li HS, Fagaly T, Zhou L, Wu JY and Rao Y (2000). Embryonic expression and extracellular secretion of Xenopus Slit. Neuroscience 96:231-236.

13) Chen J, Wen L, Dupuis S, Wu JY and Rao Y (2001). The N-terminal leucine rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. J. Neurosci. 21:1548-1556.

14) Hirata T, Fujisawa H, Wu JY and Rao Y (2001). Independence of short-range guidance for olfactory bulb axons from repulsive factor Slit. J. Neurosci. 21: 2373-2379.

15) Wu JY, Feng L, Park H-T, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Z, Zhang X-C and Rao Y (2001). The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410:948-952.

16) Wong K, Ren X-R, Huang Y-Z, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong W-C and Rao Y (2001). Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107:209-221.

17) Zhu Y, Yu T, Zhang X-C, Nagasawa T, Wu JY and Rao Y (2002). Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nature Neurosci. 5:719-720.

18) Sang Q, Wu JY, Rao Y, Hsueh, Y-P and Tan S-S (2002). Slit promotes branching and elongation of neurites of interneurons but not projection neurons from the developing telencephalon. Mol Cell Neurosci 21:250-65.

19) Jin Z, Zhang J, Klar A, Chédotal A, Rao Y, Cepko CL and Bao Z-Z (2003). Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development 130: 1037-1048.

20) Yuan W, Rao Y, Babiuk RP, Greer J, Wu JY and Ornitz DM (2003). A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci USA 100: 5217-5222.

21) Ward M, McCann C, DeWulf M, Wu JY and Rao Y (2003). Distinguishing between directional guidance and motility regulation in neuronal migration. J Neurosci 23:5170-5177.

22) Liu G and Rao Y (2003). Neuronal migration from the forebrain to the olfactory bulb requires a new attractant persistent in the olfactory bulb. J Neurosci 23:6651– 6659.

23) Wang B, Xiao Y, Ding B-B, Zhang N, Yuan X-B, Gui L, Qian, K-X, Duan S, Chen  Z, Rao Y and Geng J-G (2003). Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 4:19-29.

24) DeBellard ME, Rao Y and Bronner-Fraser M (2003). Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells. J Cell Biol 162:269-279.

25) Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien C-B, Wu JW, Urness LD and Li DY (2003). Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev Biol 261: 251-267.

26) Guan H, Zu G, Xie Y, Tang H, Johnson M, Xu X, Kevil C, Xiong W-C, Elmets C, Rao Y, Wu JY and Hui Xu H (2003). Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses.  J Immunol 171:6519-6526.

27) Zhu Y, Yu T and Rao Y (2004). Developmental regulation of EGL migration through a switch in cellular responsiveness to cerebellar meninges. Dev Biol 267:153-64.

28) Ward ME, Wu JY and Rao Y (2004). Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci USA 101:970-974.

29) Prasad A, Fernandis AZ, Rao Y and Ganju RK (2004). Slit-3 protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells. J Biol Chem 279:9115-24.

30) Molle KD, Chédotal A, Rao Y, Lumsden A, and Wizenmann A (2004). Local inhibition guides the trajectory of early longitudinal tracts in the developing chick brain. Mech Dev 121:143-156.

31) Kanellis J, Garcia GE, Li P, Parra G, Wilson CB, Rao Y, Han S, Smith CW, Johnson RJ, Wu JY and Feng L (2004). Modulation of inflammation by Slit protein in vivo in experimental crescentic glomerulonephritis. Am J Pathol 165:341-52.

32) Liu G, Beggs H, Jürgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu JY and Rao Y (2004). Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons. Nature Neurosci 7:1222-1232.

33) Li W, Lee J, Vikis HG, Lee S-H, Liu G., Aurandt J, Shen T-L, Fearon ER, Guan J-L, Han M, Rao Y, Hong K and Guan KL (2004). Activation of FAK and Src are receptor proximal events required for netrin signaling. Nature Neurosci 7:1213-1221.

34) Jiang H, Guo W, Liang XH and Y Rao (2005). Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3b and its upstream regulators. Cell 120:123-135.

35) Ding YQ, Kim JY, Xu YS, Rao Y and Chen ZF (2005). Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord. Development 132: 2047-2056.

36) Lin L, Rao Y and Isacson O. (2005). Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Mol Cell Neurosci 28:547-55.

37) Ward ME, Jiang H and Rao Y (2005). Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration. Mol Cell Neurosci 30:378-387.

38) Kim TH, Lee HK, Seo IA, Bae HR, Suh DJ, Wu JY, Rao Y, Hwang KG and Park HT (2005) Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. J Neurochem 95:1-8.

39) Werbowetski-Ogilvie TE, Sadr MS, Jabado N, Angers-Loustau A, Agar NYR, Wu J, Bjerkvig R, Antel JP, Faury D, Rao Y and Del Maestro RF (2006). Inhibition of medulloblastoma cell invasion by Slit. Oncogene 25: 5103-5112.

40) Liu G, Li W, Gao X, Li X, Jurgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL and Rao Y (2007) p130(CAS) is required for netrin signaling and commissural axon guidance. J Neurosci 27:957-68.

41) Guo W, Jiang H, Gray V, Dedhar S and Rao Y (2007). Role of the integrin-linked kinase (ILK) in determining neuronal polarity. Dev Biol 306:457-468.

42) Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim H-G, Fan Y, Xi Q, Li Q-G, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yank J, Giltay JC, Wijmeng C, V.M. de Jong TVM, Feather SA, Woolf AS, Rao Y, Lupsk JR, Eccles MR, Quad BJ, Gusell JF, Morton C and Maas RL (2007). Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet 80:616–632.

43) Li X, Gao X, Liu G, Xiong W, Wu JY and Rao Y (2008). Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nature Neurosci 11:28-35.

44) Zhou C, Rao Y and Rao Y (2008). A subset of octopaminergic neurons are important for Drosophila aggression. Nature Neurosci 11:1059-1061.

45) Liu G, Li W, Wang L, Kar A, Guan KL, Rao Y and Wu JY. (2009). DSCAM functions as a netrin receptor in commissural axon pathfinding. Proc Natl Acad Sci USA 106:2951-6.

46) Yuasa-Kawada J, Kinoshita-Kawada M, Rao Y and Wu JY (2009). Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration Proc Natl Acad Sci USA 106:14530-14535.

47) Yuasa-Kawada J, Kinoshita-Kawada M, Wu G, Rao Y and Wu JY (2009). Midline crossing and Slit responsiveness of commissural axons require USP33. Nature Neurosci 12:1087-9.

48) Liu Y, Jiang Y, Si Y, Kim J-Y, Chen Z-F and Rao Y (2011). Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brain of male mice. Nature 472:95-99.

49) Liu WW, Liang XH, Li YN, Gong JX, Yang Z, Zhang YH, Zhang JX and Rao Y (2011). Social regulation of aggression mediated by pheromonal activation of Or65a olfactory receptor neurons in Drosophila. Nature Neurosci 14:896-902.

50) Masuyama K, Zhang Y, Rao Y and Wang JW (2012). Mapping neural circuits with activity-dependent nuclear import of a transcription factor. J Neurogenet 26:89-102.

51) Zhou C, Huang H, Kim SM, Lin H, Meng X, Chiang A-S, Wang JW, Jiao R and Rao Y (2012) Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J Neurosci 32:14281-14287.

52) Zhang SS, Liu Y and Rao Y (2013). Serotonin signaling in the brain of adult female mice is required for sexual preference. Proc Natl Acad Sci USA 110:9968-9973.

53) Gasque G, Conway S, Huang J, Rao Y and Vosshall (2013) Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target. Scientific Reports 3:2120/doi:10.1038/srep02120.

54) Ishimoto H, Wang Z, Rao Y, Wu C-F and Kitamoto T (2013) A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain. PLoS Genet 9:e1003843. doi:10.1371/journal.pgen.1003843.

55) Zhu ZJ, Wang YY, Cao ZJ, Chen BQ, Cai HQ, Wu YH and Rao Y (2016). Cue-independent memory impairment by reactivation-coupled interference in human declarative memory. Cognition 155:125-134.

56) Li Z, Yang H-Y, Wang Y, Zhang M-L, Liu X-R, Xiong Q, Zhang L-N, Jin Y, Mou L-S, Liu Y, Li R-F, Rao Y and Dai Y-F (2017). Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting. J Biomed Res 31:445-452.

57) Qian YJ, Cao Y, Deng BW, Yang G, Li J, Xu R, Zhang D, Huang J and Rao Y (2017). Sleep homeostasis regulated by 5HT2b receptor in a small subset of neurons in the dorsal fan-shaped body of Drosophila. eLife 6:e26519.

58) Chen BQ, Zhu, ZJ, Wang YY, Ding XH, Guo XB, He MG, Fang W, Zhou SB, Zhou Q, Huang AL, Chen TM, Ni DS, Gu YP, Liu JN, Lei H and Rao Y (2018). Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity. J Hum Genet 63:605-619.

59) Zhang X, Yan HM, Huang ZL and Rao Y (2018). Independence of 5HT involvement in sleep and arousal from thermoregulation in mice. Mol Pharmacol 93:657-664.

60) Zhu ZJ, Chen BQ, Yan HM, Fang W, Zhou Q, Zhou SB, Lei H, Huang AL, Chen TM, Gao TM, Chen L, Chen JY, Ni DS, Gu YP, Liu JN, Zhang WX and Rao Y (2018). Multi-level genomic analyses suggest new genetic variants involved in human memory. Eur J Hum Genet 26:1668-1678.

61) Chen BQ, Zhu ZJ, Na R, Fang W, Zhang W, Zhou Q, Zhou SB, Lei H, Huang AL, Chen TM, Ni DS, Gu YP, Liu JN, Fang F and Rao Y (2018). Genomic analysis of visual cognition: perceptual switching and top-down control. J Neurosci 38:9668-9678.

62) Deng BW, Li Q, Liu XX, Cao Y, Li BF, Qian YJ, Xu R, Mao RB, Zhou EX, Zhang WX, Huang J and Rao Y (2019) Chemoconnectomics: mapping chemical transmission in Drosophila. Neuron 101:876-893.

63) Dai XHM, Zhou EX, Yang W, WX Zhang and Rao Y (2019) D-Serine promotes sleep through the NMDA receptor in Drosophila melanogaster. Nat Comm 10:1986.

64) Zhu ZJ, Chen BQ, Na R, Fang W, Zhang WX, Zhou Q, Zhou SB, Lei H, Huang AL, Chen TM, Gao TM, Chen L, Ni DS, Gu YP, Liu JN, Chen JY, Rao Y and Fang F (2020). Heritability of human visual contour integration—an integrated genomic study. Eur J Hum Genet 27:1867-1875.

65) Dai XHM, Zhou EX, Yang W, Deng BW, Li Q, Liu XX, Zhang WX and Rao Y (2021). Molecular resolution of a behavioral paradox: sleep and arousal are regulated by distinct acetylcholine receptors in different neurons of Drosophila. Sleep 10:1093.

66) Liu YX, Wang TV, Cui YF, Gao SX and Rao Y (2022). Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3. J Biol Chem 298:101929.

67) Liu YX, Wang TV, Cui YF, Li CY, Jiang LF and Rao Y (2022). STE20 phosphorylation of AMPK related kinases revealed by biochemical purifications combined with genetics. J Biol Chem 298:101928.

68) Liu ZY, Jiang LF, Li CY, Li CG, Yang JQ, Yu JJ, Mao RB and Rao Y (2022). LKB1 is physiologically required for sleep from Drosophila melanogaster to the Mus musculus. Genetics 221: iyac082.

69) Liu Y, Shan L, Liu T, Li J, Chen YC, Sun CH, Yang CJ, Bian XL, Niu YY, Zhang C, Xi JZ and Rao Y (2023) Molecular and cellular mechanisms of the first social relationship: a conserved role of 5-HT from mice to monkeys, upstream of oxytocin. Neuron 111:1468-1685.

70) Jia X, Zhu J, Bian X, Liu S, Yu S, Liang W, Jiang L, Mao R and Rao Y (2023). Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability. eLife 12:RP86972.

71) Yu J, Wang TV, Gao R, Li CG, Liu HJ, Yang L, Liu YX, Cui YF, Chen RP and Rao Y (2023). Biochemical and chemical biological approaches to study sleep: site-specific desphosphorylation by calcineurin regulates mammalian sleep. BioRxiv doi: 10.1101/202306.19.545643.