Institute of Molecular Physiology
Shenzhen Bay Fellow
zengjz@szbl.ac.cn
Timeline
2024 – Present Shenzhen Bay Laboratory Shenzhen Bay Fellow
2022-2024 Shenzhen Bay Laboratory Postdoc
2021-2022 CoStone Capital
2015-2021 Peking-Tsinghua Center for Life Sciences PhD
2011-2015 Hunan University Bachelor
Research Areas
Jianzhi Zeng's research group is dedicated to developing neuroimaging techniques to explore the molecular dynamics of critical signals in both pathological and physiological processes.
1. Development of fluorescent protein-based indicators.
2. Investigation of the etiology and intervention of neuroinflammation.
3. Exploration of the circuit and molecular mechanisms of learning and memory.
Highlights
Development of fluorescent dopamine sensor. It enables the detection of dopamine molecular dynamics in olfactory perception, fear behavior, learning and memory, and social behavior in live fruit flies, zebrafish, and mice (Cell, 2018). This work was selected as one of the 'Top Ten Scientific Advances in Chinese Life Sciences in 2018' and was featured in a popular science report by the People's Daily.
Focusing on the effective time interval of 'bell and food' in Pavlovian learning, we revealed the molecular and neural circuit mechanisms by which serotonin regulates the time window for learning and memory (Neuron, 2023). This research was featured in a popular science report by the People's Daily.
Honors
2024 Excellent Postdoctoral Fellow in Shenzhen City
2023 Junior Talent Program, China Association for Science and Technology
2023 Third Prize of the National Young Researcher in Physiology, C. C. Chang Foundation, Chinese Physiological Society
2023 The Hsiang-Tung Chang Outstanding Graduate Thesis Award in Neuroscience, Chinese Neuroscience Society
2021 Ray Wu Prize, Ray Wu Foundation
Media
1. 和北大腦科學博士聊聊情緒與激素 ft. 曾健智｜TIANYU2FM - E093
https://www.youtube.com/watch?v=xyctDbn9EAc
2. 脑师说 当代神经科学技术 第1期｜神经递质光学探针
https://www.youtube.com/watch?v=nvbXBqU3jGM
Selected Publications
1. Zeng, J.*#, Li, X.*, Zhangren, Z., ... & Li, Y.# (2023). Local 5-HT signal bi-directionally modulates the coincident time window of associative learning. Neuron. (*co-first author; #co-corresponding author)
2. Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.# (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering.
3. Sun, F.*, Zeng, J.*, Jing, M.*, Zhou, J., Feng, J., Owen, S., ... & Li, Y.# (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell. (*co-first author)
Full publication list:
https://scholar.google.com.hk/citations?user=c4lK_QoAAAAJ&hl=zh-CN